PETER A. RICE, M.D.; DON L. GOLDENBERG, M.D.
Grant support: by grants AI 15633 and Biomedicine Research Support Grant RRO 5569 from the National Institutes of Health.
▸Requests for reprints should be addressed to Peter A. Rice, M.D.; The Maxwell Finland Laboratory for Infectious Diseases, 774 Albany Street; Boston, MA 02118.
RICE P., GOLDENBERG D.; Clinical Manifestations of Disseminated Infection Caused by Neisseria gonorrhoeae Are Linked to Differences in Bactericidal Reactivity of Infecting Strains. Ann Intern Med. 1981;95:175-178. doi: 10.7326/0003-4819-95-2-175
Download citation file:
Published: Ann Intern Med. 1981;95(2):175-178.
Twenty-nine patients with disseminated gonococcal infection were classified into two clinical groups at the time of hospitalization: 13 with suppurative arthritis and 16 with only tenosynovitis, dermatitis, or both. Patients with suppurative arthritis had significantly less tenosynovitis and dermatitis (p < 0.02). Strains of Neisseria gonorrhoeae isolated from the two groups of patients were each repetitively tested in a bactericidal assay using fresh frozen sera obtained from 10 normal human volunteers. Although strains causing disseminated gonococcal infection in general are serum resistant, those isolated from patients with suppurative arthritis were significantly less resistant (p < 0.01) than those isolated from patients with only tenosynovitis and dermatitis. Differences in strains as reflected by variation in resistance to normal human sera may cause these strains to produce diverse clinical manifestations.
to gain full access to the content and tools.
Learn more about subscription options.
Register Now for a free account.
Infectious Disease, Sexually Transmitted Infections.
Results provided by:
Copyright © 2016 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use
This PDF is available to Subscribers Only