MORIE A. GERTZ, M.D.; ROBERT M. PETITT, M.D.; ALVARO A. PINEDA, M.D.; MARK R. WICK, M.D.; EDWIN A. BURGSTALER
GERTZ MA, PETITT RM, PINEDA AA, WICK MR, BURGSTALER EA. Vinblastine-Loaded Platelets for Autoimmune Hemolytic Anemia. Ann Intern Med. 1981;95:325-326. doi: 10.7326/0003-4819-95-3-325
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Published: Ann Intern Med. 1981;95(3):325-326.
Treatment of autoimmune hemolytic anemia with corticosteroids (1), splenectomy (2), immune suppression (3), and plasma exchange (4), serially or in combination, often yields partial or short remissions. We describe a patient in whom refractory autoimmune hemolytic anemia was moderated by selective impairment of the mononuclear-phagocyte system. The success of this approach, initially proposed for treatment of immune thrombocytopenic purpura (5), suggests that erythrocytes and platelets share a common site of immune destruction and that the rate of this destruction is determined by the phagocyte.
A 42-year-old housewife noted symptoms of anemia in August 1977 (see Figure 1). Hemoglobin was 7
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Hematology/Oncology, Red Cell Disorders.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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