JAMES W. FINDLING, M.D.; J. BLAKE TYRRELL, M.D.; DAVID C. ARON, M.D.; PAUL A. FITZGERALD, M.D.; CLINTON W. YOUNG, M.D.; PETER G. SOHNLE, M.D.
FINDLING JW, TYRRELL JB, ARON DC, FITZGERALD PA, YOUNG CW, SOHNLE PG. Fungal Infections in Cushing's Syndrome. Ann Intern Med. 1981;95:392. doi: 10.7326/0003-4819-95-3-392_1
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Published: Ann Intern Med. 1981;95(3):392.
To the editor: We read with interest the report by Anthony and Greco (1) and describe another, more frequent infectious complication of spontaneous Cushing's syndrome. We have observed that superficial cutaneous or mucosal fungal infections occur commonly in Cushing's syndrome and are often the initial manifestation of endogenous hypercortisolism, frequently predating the diagnosis.
We evaluated 41 consecutive patients with spontaneous Cushing's syndrome treated at the General Clinical Research Center of the University of California, San Francisco, from January 1976 to March 1980—27 patients by retrospective chart review (those seen before June 1979), and 14 prospectively. Only those patients with positive
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