FREDERICK L. DUNN, M.D.; ANGEL PIETRI, M.D.; PHILIP RASKIN, M.D.
Plasma lipid and lipoprotein-cholesterol levels were measured in 10 insulin-dependent (Type I) diabetics taking their usual dose of conventionally administered insulin during 6 months of a continuous subcutaneous insulin infusion delivered with a small, portable, battery-powered pump. With this insulin delivery system we were able to provide near normal glucoregulation 24 hours a day for the entire study. This improved glucoregulation resulted in significant reductions in total plasma cholesterol and triglyceride, and very low density and low density lipoprotein-cholesterol levels within 2 to 4 weeks of treatment. These changes persisted for the entire 6 months of observation. High density lipoprotein-cholesterol levels rose significantly after 2 months of treatment and continued to increase during the 6-month study. These changes in plasma lipid and lipoprotein-cholesterol levels in response to treatment with continuous subcutaneous insulin infusion would favorably alter the predicted risk for the development of premature atherosclerosis in these patients.
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DUNN FL, PIETRI A, RASKIN P. Plasma Lipid and Lipoprotein Levels with Continuous Subcutaneous Insulin Infusion in Type I Diabetes Mellitus. Ann Intern Med. 1981;95:426–431. doi: 10.7326/0003-4819-95-4-426
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Published: Ann Intern Med. 1981;95(4):426-431.
Cardiology, Coronary Risk Factors, Diabetes, Endocrine and Metabolism.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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