IRWIN KLEIN, M.D.; GERALD S. LEVEY, M.D.
KLEIN I, LEVEY GS. Thyroxine Therapy, Hypothyroid Patients, and Coronary Revascularization. Ann Intern Med. 1982;96:250-251. doi: 10.7326/0003-4819-96-2-250_2
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Published: Ann Intern Med. 1982;96(2):250-251.
To the editor: In their article, Hay and coauthors (1) address the question of the safety and the appropriateness of thyroid hormone replacement in patients with incapacitating coronary artery disease. They conclude that in this limited group of hypothyroid patients with atherosclerotic cardiovascular disease, thyroid hormone replacement is accompanied by complications that outweigh the therapeutic benefits of attaining a euthyroid state. Unfortunately, this study was retrospective and suffers from the serious limitations inherent in such analysis.
The 18 patients selected had had aortocoronary artery bypass surgery and a coexist diagnosis of hypothyroidism. The indications used to select patients for coronary
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