JAMES C. WADE, M.D.; BARBARA NEWTON, R.N.; COLIN McLAREN, Ph.D.; NANCY FLOURNOY, M.S.; RONALD E. KEENEY, M.D.; JOEL D. MEYERS, M.D.
Acyclovir, a new antiviral agent, was compared to a placebo in a randomized double-blind trial of treatment for culture-proven herpes simplex virus infection after marrow transplantation. Patients received either intravenous acyclovir at 750 mg/m2 body surface area per day or a placebo for 7 days. Thirteen of 17 patients given acyclovir had a beneficial response as compared with two of 17 given the placebo (p < 0.01). The duration of positive cultures was shorter among acyclovir recipients (3 versus 17 days, p < 0.00005). Also shorter were the median days to resolution of pain (10 versus 16 days, p = 0.03), to crusting of lesions (7 versus 14 days, p = 0.01), and to total healing (14 versus 28 days, p = 0.03). No acyclovir toxicity was observed. Recurrent infection was common. Acyclovir provided significant antiviral and clinical efficacy without toxicity in highly immunosuppressed patients but had no effect on virus latency.
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WADE JC, NEWTON B, McLAREN C, FLOURNOY N, KEENEY RE, MEYERS JD. Intravenous Acyclovir to Treat Mucocutaneous Herpes Simplex Virus Infection After Marrow Transplantation: A Double-Blind Trial. Ann Intern Med. 1982;96:265–269. doi: 10.7326/0003-4819-96-3-265
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Published: Ann Intern Med. 1982;96(3):265-269.
Hematology/Oncology, Infectious Disease.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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