RICHARD J. KOLETSKY, M.D.; ROBERT G. DLUHY, M.D.; FRANK R. CRANTZ, M.D.; GORDON H. WILLIAMS, M.D.
KOLETSKY RJ, DLUHY RG, CRANTZ FR, WILLIAMS GH. Cortisol Suppression Test in Patients with Elevated Adrenocorticotropic Hormone Levels. Ann Intern Med. 1982;96:277-280. doi: 10.7326/0003-4819-96-3-277
Download citation file:
Published: Ann Intern Med. 1982;96(3):277-280.
Increased adrenocorticotropic hormone (ACTH) levels after bilateral adrenalectomy could be secondary to a pituitary tumor, under replacement with cortisol, or an abnormality in the hypothalmic-pituitary-adrenal feedback loop. To distinguish between these possibilities, ACTH levels were measured before and after cortisol infusion (20 mg/h for 4 hours) in five groups: normal volunteers; patients with idiopathic adrenal insufficiency; and with bilateral adrenalectomy for Cushing's syndrome with no roentgenographic evidence of pituitary tumor, with pituitary tumors, and with equivocal roentgenographic studies (suspect pituitary tumors). Control ACTH levels in all groups of patients were higher than in normal volunteers but there was overlapping. Cortisol infusion suppressed ACTH in all subjects but the reductions in the last two groups were less than in the first three. The cortisol suppression test appears to be useful in determining whether increased ACTH level after adrenalectomy is due to a pituitary tumor.
Learn more about subscription options.
Register Now for a free account.
Adrenal Disorders, Endocrine and Metabolism, Neurology.
Results provided by:
Copyright © 2017 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use
This PDF is available to Subscribers Only