JAMES B. PUCKETT, M.D.; M. ROBERT COOPER, M.D.; JOHN J. STUART, M.D.; WALLACE C. WU, M.B.B.S.; J. MICHAEL STERCHI, M.D.
PUCKETT JB, COOPER MR, STUART JJ, WU WC, STERCHI JM. Pyrimethamine, Sulfadiazine , and Villous Atrophy of the Jejunum. Ann Intern Med. 1982;96:380. doi: 10.7326/0003-4819-96-3-380_1
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Published: Ann Intern Med. 1982;96(3):380.
To the editor: Pyrimethamine and sulfadiazine are useful in treating ocular toxoplasmosis. We recently cared for a patient who was treated for ocular toxoplasmosis with pyrimethamine and sulfadiazine and developed scalp alopecia, bone marrow hypoplasia, and a malabsorption syndrome with total villous atrophy of the jejunum.
A 28-year-old woman was treated in 1974 for occular toxoplasmosis with pyrimethamine and sulfadiazine and developed scalp alopecia and diarrhea that persisted for 1 month. In August 1979 she had increased activity of her ocular toxoplasmosis and again was treated with pyrimethamine and sulfadiazine. On the third day of therapy she developed fever, scalp
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