DAVID F. GARDNER, M.D.; ROBERT L. CARITHERS, M.D.; ROBERT D. UTIGER, M.D.
Grant support: in part by grants AM26112 and RR00065, U.S. Public Health Service.
▸Requests for reprints should be addressed to David F. Gardner, M.D.; Box 102, MCV Station; Richmond, VA 23298.
GARDNER D., CARITHERS R., UTIGER R.; Thyroid Function Tests in Patients with Acute and Resolved Hepatitis B Virus Infection. Ann Intern Med. 1982;96:450-452. doi: 10.7326/0003-4819-96-4-450
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Published: Ann Intern Med. 1982;96(4):450-452.
Serum thyroid hormones and thyroid hormone binding were sequentially measured in 20 patients with acute hepatitis B infection. Criteria to select patients consisted of a positive test for hepatitis B surface antigen, aspartate aminotransferase (AsAT) concentration greater than 400 U/L during the acute illness, and available serum specimens after recovery. The mean serum thyroxine (T4) concentration (±SE) was 12.5 ± 0.6 µ/dL during acute infection and 7.4 ± 0.3 µ/dL after recovery (p < 0.001), whereas mean free T4 index values did not significantly differ. The mean serum thyroxine-binding globulin (TBG) concentration was significantly increased (p < 0.001) during acute illness and accounted for the reversible increase in the thyroid-hormone-binding capacity of serum and the increased serum T4 concentrations. The rise in serum TBG correlated with the rise in AsAT during the acute illness (p < 0.04) suggesting nonspecific release of these proteins from injured hepatocytes. The mean free triiodothyronine (T3) index was decreased during acute hepatitis (p < 0.001) and returned to normal after recovery, indicating that acute hepatitis B infection, like other nonthyroidal illnesses, is associated with decreased T4 to T3 conversion in peripheral tissues.
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Endocrine and Metabolism, Infectious Disease, Thyroid Disorders.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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