MELVIN J. PRINCE, M.D.; PHILLIP C. SCHAEFER, Ph.D.; RALPH S. GOLDSMITH, M.D.; ARTHUR B. CHAUSMER, M.D., Ph.D.
PRINCE MJ, SCHAEFER PC, GOLDSMITH RS, CHAUSMER AB. Hyperphosphatemic Tumoral Calcinosis: Association with Elevation of Serum 1,25-Dihydroxycholecalciferol Concentrations. Ann Intern Med. 1982;96:586-591. doi: 10.7326/0003-4819-96-5-586
Download citation file:
Published: Ann Intern Med. 1982;96(5):586-591.
Seven siblings with hyperphosphatemic tumoral calcinosis were studied using metabolic measures. Serum phosphorus and 1,25-dihydroxycholecalciferol concentrations were significantly increased and serum parathyroid hormone and 25-hydroxycholecalciferol concentrations were significantly decreased in these subjects. Metabolic balance studies done in three of the siblings showed positive calcium and phosphorus balances, reflected by increased gastrointestinal absorption and decreased renal excretion. These data suggest that a hereditary abnormality of vitamin D metabolism may be present in patients with hyperphosphatemic tumoral calcinosis. Failure of the normal feedback mechanism regulating the 25-hydroxy-1-alpha-hydroxylase enzyme is suggested as the major cause. Although this defect could lead to many of the metabolic abnormalities seen in these patients, the overall contribution of altered vitamin D metabolism to the pathogenesis of tumoral calcinosis is not fully understood.
Learn more about subscription options.
Register Now for a free account.
Results provided by:
Copyright © 2017 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use
This PDF is available to Subscribers Only