GARY R. GIBSON, M.D.; J. BEATTY HUNTER, M.D.; DANIEL S. RAABE, M.D.; DEBORAH L. MANJONEY, M.D.; FRANK P. ITTLEMAN, M.D.
GIBSON GR, HUNTER JB, RAABE DS, MANJONEY DL, ITTLEMAN FP. Methemoglobinemia Produced by High-Dose Intravenous Nitroglycerin. Ann Intern Med. 1982;96:615-616. doi: 10.7326/0003-4819-96-5-615
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Published: Ann Intern Med. 1982;96(5):615-616.
The intravenous form of nitroglycerin has recently become available for general use. The ease of administration and well-documented efficacy of this agent in treating acute ischemic heart disease has led to its widespread use. Limitations on dosage of nitroglycerin have been related to its hemodynamic properties. Although the relation between certain nitrites and methemoglobinemia is well known, toxic doses of nitroglycerin have not been established. We report on the occurrence of methemoglobinemia, another reason for limiting the dose of nitroglycerin.
A 58-year-old man was admitted to a local hospital with a subendocardial myocardial infarction. In the hospital he developed rest
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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