DANIEL GLINOER, M.D.
GLINOER D. Replacement Doses of Levothyroxine. Ann Intern Med. 1982;96:682-683. doi: 10.7326/0003-4819-96-5-682_2
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Published: Ann Intern Med. 1982;96(5):682-683.
To the editor: We read with interest the article by Rosenbaum and Barzel on levothyroxine replacement doses for primary hypothyroidism (1). Although their data emphasize quite rightly the need for reliable indices for correctly adjusting long-standing hormone replacement doses, they also raise several questions.
First, the highest levothyroxine doses required (shown in their Figure 1) were given to two young subjects, 15 and 30 years of age. Were these two patients the ones with congenital hypothyroidism? If this were so, we would recommend caution in the interpretation of basal thyrotropin levels in such patients because follow-up data of patients with
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