ROBERT J. CLUXTON, PHARM.D.; JOSÉ O. RIVERA, PHARM.D.; WOLFGANG A. RITSCHEL, PH.D.; AMADEO J. PESCE, PH.D.; IRWIN B. HANENSON, M.D.
CLUXTON RJ, RIVERA JO, RITSCHEL WA, PESCE AJ, HANENSON IB. Cimetidine-Theophylline Interaction. Ann Intern Med. 1982;96:684. doi: 10.7326/0003-4819-96-5-684_1
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Published: Ann Intern Med. 1982;96(5):684.
To the editor: Recent reports have shown that cimetidine decreases theophylline clearance (1-3), and it is suggested that the decrease is caused by an inhibition of hepatic metabolism by cimetidine or its metabolites (2, 4). We report two cases that provide additional information on the reversibility and potential mechanism of this drug interaction.
Patient 1: A 50-year-old black woman with a severe asthma attack was admitted to the medicine service on 1 July 1981. She had been discharged from the hospital on 25 June after treatment for upper gastrointestinal bleeding, for which cimetidine, 300 mg orally four times a day,
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