HUIBERT J. DINANT, M.D.; JOHN L. DECKER, M.D.; JOHN H. KLIPPEL, M.D.; JAMES E. BALOW, M.D.; PAUL H. PLOTZ, M.D.; ALFRED D. STEINBERG, M.D.
Grant support: Dr. Dinant was supported by the Netherlands League Against Rheumatism.
▸Requests for reprints should be addressed to John L. Decker, M.D.; Building 10, Room 9N218, National Institutes of Health; Bethesda, MD 20205.
DINANT HJ, DECKER JL, KLIPPEL JH, BALOW JE, PLOTZ PH, STEINBERG AD. Alternative Modes of Cyclophosphamide and Azathioprine Therapy in Lupus Nephritis. Ann Intern Med. 1982;96:728-736. doi: 10.7326/0003-4819-96-6-728
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Published: Ann Intern Med. 1982;96(6_part_1):728-736.
Forty-one patients with systemic lupus erythematosus and glomerulonephritis were studied in a randomized drug trial. Thirteen patients received prednisone only (Group I), 16 received oral cyclophosphamide and oral azathioprine (1 mg/kg body weight d of each initially) (Group 2), and 12 were given boluses of intravenous cyclophosphamide (0.5 to 1.0 g/m2 body surface area every 3 months) (Group 3). The mean observation period was 42 months (range 1 to 6.5 years). Renal function deteriorated in four of 12 patients in Group 1 and three of 27 patients in Groups 2 and 3 (p = 0.114). By life-table analysis, 86% of the entire group survived 5 years after entry to the study. Marked hypertension, fluctuating changes in serum creatinine, erratic changes in levels of antibody to DNA, reduced C3 levels, increasing proteinuria or sustained hematuria, and flares of extrarenal disease activity occurred more commonly in Group 1. Infectious complications were not commoner in Groups 2 and 3. We conclude that any marginal benefits produced by the programs tested cannot be shown in this class of patients without markedly increasing the sample size. Our current studies involve more vigorous treatment of patients with more acute disease and less treatment during prolonged periods of relatively good health.
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Nephrology, Rheumatology, Autoimmune Kidney Disease, Lupus Erythematosus.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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