ROBERT G. DLUHY, M.D.; GORDON H. WILLIAMS, M.D.
DLUHY RG, WILLIAMS GH. Cushing's Syndrome and the Changing Times. Ann Intern Med. 1982;97:131-133. doi: 10.7326/0003-4819-97-1-131
Download citation file:
Published: Ann Intern Med. 1982;97(1):131-133.
Although Cushing's syndrome represents a group of diseases, the hypercortisolism can be viewed more simply as a consequence of a primary adrenal neoplasm or of continuous adrenocorticotropic hormone (ACTH) stimulation leading to bilateral adrenal hyperplasia. The ACTH hypersecretion may be marked, as in neoplasms that secrete ACTH "ectopically" (primarily lung neoplasms). On the other hand, pituitary ACTH secretion may be modestly increased or "inappropriately" normal in the setting of elevated Cortisol levels, suggesting an abnormality in the negative feedback relation between Cortisol and ACTH in these patients (so-called idiopathic hyperplasia or Cushing's disease). That there may be abnormal regulation of
Learn more about subscription options.
Register Now for a free account.
Adrenal Disorders, Endocrine and Metabolism.
Results provided by:
Copyright © 2017 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use
This PDF is available to Subscribers Only