ARLENE A. MCLEAN, PH.D.; RAYMOND SHAW, PH.D.
To the editor: The paper by Francis and associates (1) in this issue shows the safety and efficacy of inactivated hepatitis B vaccine in a large multi-center trial. A disturbing finding is the lower than expected immunogenicity of the vaccine. Factors that could affect the potency of the vaccine were carefully examined. The purpose of this letter is to summarize those findings.
Our investigations centered on the shipment and storage conditions of the vaccine, for three reasons. First, it has been shown that male homosexuals respond well to 20-µg doses of vaccine (SZMUNESS W, STEVENS CE. Personal communication). Second, vaccine
Learn more about subscription options.
Register Now for a free account.
MCLEAN AA, SHAW R. Hepatitis B Virus Vaccine. Ann Intern Med. 1982;97:451. doi: 10.7326/0003-4819-97-3-451_1
Download citation file:
Published: Ann Intern Med. 1982;97(3):451.
Copyright © 2017 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use
This PDF is available to Subscribers Only