J.D. BITRAN, M.D.; D.L. SWEET, M.D.; J. VARDIMAN, M.D.; H.M. GOLOMB, M.D.; J.E. ULTMANN, M.D.
BITRAN J, SWEET D, VARDIMAN J, GOLOMB H, ULTMANN J. Histiocytic Lymphoma: Response to Chemotherapy. Ann Intern Med. 1982;97:617-618. doi: 10.7326/0003-4819-97-4-617_3
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Published: Ann Intern Med. 1982;97(4):617-618.
To the editor: Advanced diffuse histiocytic lymphoma is curable when treated with combination chemotherapy (1). There is a small risk (13%) of recurrent lymphoma within the first 36 months in patients with a complete response to chemotherapy. Usually, reinstitution of the initial chemotherapeutic regimen may control recurrent lymphoma. Although patients with nodular lymphoma (follicular center lymphoma) may show conversion to a diffuse histologic form (3), conversion of diffuse histiocytic lymphoma to a nodular histologic form has not been reported.
In 1980, we reported the results of treatment with the cyclophosphamide, vincristine, methotrexate with leucovorin rescue, and cytarabine (COMLA) regimen in
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