DAVID BAR-OR, M.D.; KENNETH KULIG, M.D.; JOHN A MARX, M.D.; PETER ROSEN, M.D.
BAR-OR D, KULIG K, MARX JA, ROSEN P. Precipitation of Verapamil. Ann Intern Med. 1982;97:619. doi: 10.7326/0003-4819-97-4-619_1
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Published: Ann Intern Med. 1982;97(4):619.
To the editor: Verapmil has been recently approved by the FDA for the treatment of supraventricular tachycardia. Adverse reactions have occurred when verapamil has been used with various other drugs such as intravenous beta blockers (1), and calcium and vitamin D (2). Compatibility of verapamil with other additives has been reported (3). We report the precipitation of verapamil in an intravenous bicarbonate solution not previously described.
A patient had high-voltage shock and presented to the emergency department in stable condition, but with new onset of atrial fibrillation. The ventricular rate was 150 min. An intravenous line of 0.45 normal saline
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