S. ERIDANI, M.D.; I.D.A. JOHNSTON, M.R.C.P.; S. VILLA, B.SC.
ERIDANI S, JOHNSTON I, VILLA S. Cimetidine and Granulopoiesis. Ann Intern Med. 1982;97:620. doi: 10.7326/0003-4819-97-4-620_1
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Published: Ann Intern Med. 1982;97(4):620.
To the editor: Although there have been several reports of granulocytopenia associated with the use of cimetidine (1), inhibition of granulocyte-macrophage colony formation by in-vitro cimetidine has only recently been shown in two patients (2). We report a further case with bone marrow culture studies.
A 72-year-old man was admitted from another hospital with acute renal failure after a laparotomy for a leaking aortic aneurysm. The patient was hemodialysed daily and needed ventilation on admission. On the third day of hospitalization he developed aspiration pneumonia. Intravenous gentamicin, erythromycin, and hydrocortisone were begun with cimetidine, 100 mg/dL, as a prophylactic measure.
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