ROBERT J. SHALHOUB, M.D.; UMA RAJAN, M.B.B.S.; VO V. KIM, M.D.; EUGENE GOLDWASSER, Ph.D.; JOHN A. KARK, M.D.; LUCY D. ANTONIOU, M.D.
SHALHOUB RJ, RAJAN U, KIM VV, GOLDWASSER E, KARK JA, ANTONIOU LD. Erythrocytosis in Patients on Long-term Hemodialysis. Ann Intern Med. 1982;97:686-690. doi: 10.7326/0003-4819-97-5-686
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Published: Ann Intern Med. 1982;97(5):686-690.
Erythrocytosis was seen in two men during maintenance hemodialysis therapy for end-stage renal disease secondary to apparent chronic glomerulonephritis. Nonrenal causes of erythrocytosis such as polycythemia vera, chronic hypoxemia, high-oxygen affinity hemoglobin, and hepatoma were excluded by appropriate clinical studies. A computed tomographic scan of the abdomen showed numerous renal cysts in each patient consistent with acquired cystic disease of end-stage kidneys. Peripheral serum erythropoietin levels were elevated as measured by sensitive radioimmunoassay. The findings suggest that the erythrocytosis is caused by an erythropoietic mechanism related to the diseased kidneys. A review of the literature failed to show previous reports of this clinical association.
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Hematology/Oncology, Nephrology, Renal Replacement Therapy, Red Cell Disorders.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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