BALDEV S. SANDHU, M.B. CH.B.; RAMIRO REQUENA, M.D.
SANDHU BS, REQUENA R. Cimetidine and Hypersensitivity. Ann Intern Med. 1983;98:111. doi: 10.7326/0003-4819-98-1-111_3
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Published: Ann Intern Med. 1983;98(1):111.
To the editor: We write in reply to comments by Leftwich and Simon (1) on our report (2) of a patient with type I hypersensitivity to cimetidine (Tagamet; Smith, Kline & French, Philadelphia, Pennsylvania).
The statement that the reaction described could not be a type I hypersensitivity reaction as only 12 hours had elapsed since the initial dose of cimetidine is incorrect. Accelerated reactions (type I) may occur 1 to 72 hours after drug administration, and are usually manifested by urticaria, asthma, and occasionally morbilliform eruptions and laryngeal edema (3).
We agree that the lack of control skin testing with
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