ALBERT B. KNAPP, M.D.; WILLIAM MAGUIRE, M.D., Ph.D.; GAD KEREN, M.D.; ARTHUR KARMEN, M.D.; BARRIE LEVITT, M.D.; DENNIS S. MIURA, M.D., Ph.D.; JOHN C. SOMBERG, M.D.
KNAPP AB, MAGUIRE W, KEREN G, KARMEN A, LEVITT B, MIURA DS, et al. The Cimetidine-Lidocaine Interaction. Ann Intern Med. 1983;98:174-177. doi: 10.7326/0003-4819-98-2-174
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Published: Ann Intern Med. 1983;98(2):174-177.
Lidocaine is a widely used antiarrhythmic agent whose plasma clearance varies with changes in hepatic blood flow. Cimetidine, an H2-receptor antagonist, has been shown to decrease hepatic blood flow. To ascertain whether cimetidine affected serum lidocaine concentration, we studied 21 patients receiving lidocaine infusions and divided them into two groups. Fifteen patients received cimetidine, 300 mg every 6 hours, in addition to lidocaine; six patients received only lidocaine. In 14 of the 15 patients receiving both lidocaine and cimetidine, a rise in serum lidocaine levels was seen, whereas no change was noted in the control group. Six of the 15
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