ALBERT B. KNAPP, M.D.; WILLIAM MAGUIRE, M.D., Ph.D.; GAD KEREN, M.D.; ARTHUR KARMEN, M.D.; BARRIE LEVITT, M.D.; DENNIS S. MIURA, M.D., Ph.D.; JOHN C. SOMBERG, M.D.
Grant support: Dr. Knapp is a fellow in Gastroenterology at Brigham and Women's Hospital, Boston, Massachusetts; Dr. Somberg is an Established Investigator of the American Heart Association.
▸Requests for reprints should be addressed to John C. Somberg, M.D.; Albert Einstein College of Medicine, 1300 Morris Park Avenue; Bronx, NY 10461.
KNAPP A., MAGUIRE W., KEREN G., KARMEN A., LEVITT B., MIURA D., SOMBERG J.; The Cimetidine-Lidocaine Interaction. Ann Intern Med. 1983;98:174-177. doi: 10.7326/0003-4819-98-2-174
Download citation file:
Published: Ann Intern Med. 1983;98(2):174-177.
Lidocaine is a widely used antiarrhythmic agent whose plasma clearance varies with changes in hepatic blood flow. Cimetidine, an H2-receptor antagonist, has been shown to decrease hepatic blood flow. To ascertain whether cimetidine affected serum lidocaine concentration, we studied 21 patients receiving lidocaine infusions and divided them into two groups. Fifteen patients received cimetidine, 300 mg every 6 hours, in addition to lidocaine; six patients received only lidocaine. In 14 of the 15 patients receiving both lidocaine and cimetidine, a rise in serum lidocaine levels was seen, whereas no change was noted in the control group. Six of the 15
to gain full access to the content and tools.
Learn more about subscription options.
Register Now for a free account.
Results provided by:
Copyright © 2016 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use
This PDF is available to Subscribers Only