ELLIOTT F. WINTON, M.D.; W. RALPH VOGLER, M.D.; LEWIS GLASSER, M.D.
WINTON EF, VOGLER WR, GLASSER L. Dose in Granulocyte Transfusion. Ann Intern Med. 1983;98:257. doi: 10.7326/0003-4819-98-2-257
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Published: Ann Intern Med. 1983;98(2):257.
To the editor: In a recent article, Winston and associates (1) presented data that led them to conclude that therapeutic granulocyte transfusions offered no substantial benefit over optimal antimicrobial therapy alone in managing infected patients with granulocytopenia. We have difficulty extrapolating their observations to granulocyte transfusion therapy as given at our institution (2) and others (3) where doses of three to six times as many granulocytes are administered routinely. The authors have criticized other randomized trials of granulocyte transfusions in neutropenic patients for having too few patients. We find the major weakness of this study to be too few granulocytes
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