EFRAIN REISIN, M. D.; EDWARD D. FROHLICH, M.D.; FRANZ H. MESSERLI, M.D.; GERALD R. DRESLINSKI, M.D.; FRANCIS G. DUNN, M.D.; MARTHA M. JONES, B.S., R.D.; HUGH M. BATSON, M.D.
Grant support: in part by a grant-in-aid HL-22506, National Heart, Lung, and Blood Institute; and from a bequest from Helen Wells Andress through the Alton Ochsner Medical Foundation.
▸Requests for reprints should be addressed to Efrain Reisin, M.D.; Ochsner Medical Foundation, 1516 Jefferson Highway; New Orleans, LA 70121.
REISIN E., FROHLICH E., MESSERLI F., DRESLINSKI G., DUNN F., JONES M., BATSON H.; Cardiovascular Changes After Weight Reduction in Obesity Hypertension. Ann Intern Med. 1983;98:315-319. doi: 10.7326/0003-4819-98-3-315
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Published: Ann Intern Med. 1983;98(3):315-319.
Intravascular volumes and systemic and regional hemodynamic variables were measured before and after weight reduction in 12 patients with obesity and essential hypertension. These findings were compared with those in nine patients who did not have any weight loss. Reduction of mean arterial pressure significantly correlated with the fall in total body weight (r= 0.46, p < 0.05). Total circulating and cardiopulmonary blood volumes were significantly reduced (p < 0.05 and p < 0.01, respectively), and these changes permitted a decreased venous return and cardiac output (p < 0.01). This fall in cardiac output was directly related to a contracted total blood volume (r=0.49,p < 0.05) and decreased cardiopulmonary blood volume (r= 0.52, p < 0.05). Patients who did not lose weight showed no changes in any of these hemodynamic measurements. In addition, weight loss was associated with reduced resting circulating levels of plasma norepinephrine (p < 0.01), suggesting that diminished adrenergic function may also be related to weight reduction and its associated fall in arterial pressure.
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Cardiology, Nephrology, Hypertension, Obesity, Coronary Risk Factors.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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