DEBORAH R. DOYLE, M.D.; THOMAS L. McCURLEY, M.D.; JOHN S. SERGENT, M.D.
Thirteen reports of patients who developed polymyositis or dermatomyositis during treatment with D-penicillamine are reviewed and a fourteenth case is described. Twelve of the fourteen patients recovered after D-penicillamine was withdrawn; two patients died from cardiac involvement. Proximal muscle weakness was present in 13 patients and dermatomyositis in 4 patients. Dysphagia was the presenting symptom in 6 patients. Although D-penicillamine is useful in the management of rheumatoid arthritis, this drug should be used with caution and patients monitored closely for evidence of polymyositis or dermatomyositis.
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DOYLE DR, McCURLEY TL, SERGENT JS. Fatal Polymyositis in D-Penicillamine-Treated Rheumatoid Arthritis. Ann Intern Med. 1983;98:327–330. doi: 10.7326/0003-4819-98-3-327
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Published: Ann Intern Med. 1983;98(3):327-330.
Rheumatoid Arthritis, Rheumatology.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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