MATTHEW E. LEVISON, M.D.; CAROLINA T. MANGURA, M.D.; BENNETT LORBER, M.D.; ELIAS ABRUTYN, M.D.; EDWARD L. PESANTI, M.D.; RICHARD S. LEVY, M.D.; ROB ROY MACGREGOR, M.D.; ANDREW R. SCHWARTZ, M.D.
The clinical efficacy of clindamycin was compared with that of penicillin in a randomized study of the treatment of community-acquired putrid lung abscess. After starting therapy, patients treated with clindamycin had a shorter febrile period and fewer days of fetid sputum than patients treated with penicillin (mean 4.4 versus 7.6 days and 4.2 versus 8.0 days, respectively, p < 0.05). Four of 20 patients treated with penicillin had clinically significant pulmonary or pleural extension of their infection within 10 days after starting therapy; this was not found in any of 19 patients treated with clindamycin (p < 0.05). Penicillin treatment failed in two additional patients after 20 days of therapy. Within 1 month after treatment, 1 of 4 patients given penicillin for 3 weeks had relapse, but none of the 13 patients given clindamycin for 3 or 6 weeks, and none of the 5 patients given penicillin for 6 weeks had relapse. Overall, only 8 of 15 patients treated with penicillin who could be followed to the end of the study were cured, whereas all 13 patients treated with clindamycin who could be followed were cured (p < 0.01). These results suggest that penicillin may not be optimal therapy for anaerobic lung abscess.
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LEVISON ME, MANGURA CT, LORBER B, ABRUTYN E, PESANTI EL, LEVY RS, et al. Clindamycin Compared with Penicillin for the Treatment of Anaerobic Lung Abscess. Ann Intern Med. 1983;98:466–471. doi: 10.7326/0003-4819-98-4-466
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Published: Ann Intern Med. 1983;98(4):466-471.
Infectious Disease, Pulmonary/Critical Care.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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