JEFFREY L. CRAVER, M.D.; ROLAND VALDES Jr., Ph.D.
When digoxin therapy is discontinued, it is generally assumed that the patient's serum concentration of the drug will decrease over time with a half-life dependent on the rate of digoxin elimination. A few reports (1, 2) have noted deviations from this prediction. We describe a patient with acute renal failure who had an unanticipated twofold rise in his apparent serum concentration of digoxin during the 9 days after the last administered dose of this drug.
A 56-year-old black man with hypertension was hospitalized for atrial fibrillation complicated by embolic small bowel infarction. Several surgical procedures prolonged his hospitalization. An intravenous
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CRAVER JL, VALDES R. Anomalous Serum Digoxin Concentrations in Uremia. Ann Intern Med. 1983;98:483–484. doi: 10.7326/0003-4819-98-4-483
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Published: Ann Intern Med. 1983;98(4):483-484.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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