DENNIS M. KRIZEK, B.S.; MARGARET E. RICK, M.D.; SYBIL B. WILLIAMS, B.A.; HARVEY R. GRALNICK, M.D.
Von Willebrand's disease is a congenital bleeding disorder characterized by mild to severe bleeding, quantitative or qualitative factor VIII molecular defects, and a prolonged bleeding time (1). Type I disease is characterized by a quantitative reduction of factor VIII procoagulant activity, von Willebrand factor activity, and factor-VIII-related antigen. Although lower in quantity than normal, the factor-VIII-related antigen of type I von Willebrand's disease contains the full range of factor-VIII-related antigen multimers (0.8 X 106 to approximately 20 X 106 daltons) when assessed by sodium dodecyl sulfate agarose gel electrophoresis. Type II von Willebrand's disease is characterized by variable plasma levels
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KRIZEK DM, RICK ME, WILLIAMS SB, GRALNICK HR. Cryoprecipitate Transfusion in Variant von Willebrand's Disease and Thrombocytopenia. Ann Intern Med. 1983;98:484–486. doi: 10.7326/0003-4819-98-4-484
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Published: Ann Intern Med. 1983;98(4):484-486.
Coagulopathies, Hematology/Oncology, Platelet Disorders.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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