GlDEN KOREN, M.D.
To the editor: In his recent letter (1), Nikolic claimed that "the cardiovascular effects of Cimetidine have never been documented through organized studies addressing this problem." I draw your attention to the report by Kato and associates on various cardiovascular effects of the drug in experimental studies (2).
In dogs, Cimetidine induced various electrocardiographic changes, namely T wave augmentation, R depression, and PR prolongation. Decreases in blood pressure, cardiac rate, aortic blood flow, among many other reactions, are also reported. A dose-related vasodilation of coronary arteries was observed.
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KOREN G. Cardiovascular Effects of Cimetidine. Ann Intern Med. 1983;98:673. doi: 10.7326/0003-4819-98-5-673_1
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Published: Ann Intern Med. 1983;98(5_Part_1):673.
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