THEODORE A. KOTCHEN, M.D.; ROBERT G. LUKE, M.B., Ch.B.; COBERN E. OTT, Ph.D.; JOHN H. GALLA, M.D.; SHIRLEY WHITESCARVER, B.G.S.
Both the inhibition of renin release by sodium chloride and salt-sensitive hypertension have been attributed to sodium. We evaluated the contribution of chloride to these responses to sodium chloride. In the Sprague-Dawley rat, acute and chronic administration of sodium salts other than sodium chloride failed to suppress plasma renin activity, whereas renin was inhibited by both sodium chloride and by selective chloride (without sodium) loading. Plasma renin activity was stimulated by selective chloride depletion. Similarly, in humans, plasma renin activity was suppressed by sodium chloride but not by sodium bicarbonate infusion. In a preliminary study in the Dahl salt-sensitive rat, in contrast to sodium chloride loading, sodium bicarbonate loading failed to produce hypertension. Thus, both the renin and possibly the blood pressure responses to sodium chloride are dependent on chloride.
Learn more about subscription options.
Register Now for a free account.
KOTCHEN TA, LUKE RG, OTT CE, GALLA JH, WHITESCARVER S. Effect of Chloride on Renin and Blood Pressure Responses to Sodium Chloride. Ann Intern Med. 1983;98:817–822. doi: 10.7326/0003-4819-98-5-817
Download citation file:
Published: Ann Intern Med. 1983;98(5_Part_2):817-822.
Cardiology, Coronary Risk Factors, Hypertension, Nephrology.
Results provided by:
Copyright © 2017 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use
This PDF is available to Subscribers Only