ERIC B. BASS, A.B.; SAMUEL W. SMITH, M.D.; ROGER E. STEVENSON, M.D.; WENDELL F. ROSSE, M.D.
Hereditary spherocytosis (HS) is a form of hemolytic anemia transmitted as an autosomal dominant trait (1). To date, the HS gene has not been mapped to a specific chromosome. Kimberling and associates (2, 3) reported a family containing 14 members with both HS and a balanced translocation between the short arms of chromosomes 8 and 12 (t(8;12) (p11; p13)). This linkage between hereditary spherocytosis and the translocation would place the HS locus on chromosome 8 or chromosome 12. We report a mother and son with hereditary spherocytosis and a balanced translocation between chromosomes 3 and 8 and suggest that
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BASS EB, SMITH SW, STEVENSON RE, ROSSE WF. Further Evidence for Location of the Spherocytosis Gene on Chromosome 8. Ann Intern Med. 1983;99:192-193. doi: 10.7326/0003-4819-99-2-192
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Published: Ann Intern Med. 1983;99(2):192-193.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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