LEONARD A. GROSSMAN, M.D.; SANDRA MOSS, M.D.
GROSSMAN LA, MOSS S. Piroxicam and Hyperkalemic Acidosis. Ann Intern Med. 1983;99:282. doi: 10.7326/0003-4819-99-2-282_2
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Published: Ann Intern Med. 1983;99(2):282.
To the editor: Several nonsteroidal antiinflammatory drugs have been associated with reversible azotemia and hyperkalemia (1). Piroxicam is a new, chemically unique, nonsteroidal antiinflammatory drug in the oxicam family (2). We have observed reversible, hyperkalemic, hyperchloremic acidosis associated with piroxicam therapy in a patient with rheumatoid arthritis.
A 55-year-old man with a 25-year history of rheumatoid arthritis complicated by hypocomplementemic glomerulonephritis was hospitalized for bilateral total replacement of the hip. Therapy consisted of piroxicam, 20 mg/day, for 6 months, and chronic hypertension was controlled with propranolol, 40 to 60 mg/day. His previous arthritis treatment had included
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