HARVEY M. GOLOMB, M.D.; DANIEL CATOVSKY, M.D.; DAVID W. GOLDE, M.D.
Hairy cell leukemia, although rare, has become a well-described clinicopathologic entity since its identification in 1958 (1). Patients with the disease have circulating leukemic cells with prominent cytoplasmic projections. These cells are tartrate-resistant acid-phosphatase-positive in cytochemical tests. These cytochemical features, combined with a characteristic pattern of bone marrow involvement, are diagnostic for hairy cell leukemia (2, 3). Clinically, most patients have splenomegaly without adenopathy. Usually, a pancytopenia is present, but 10% to 20% of patients have an elevated leukocyte count, most of these leukocytes being hairy cells (4, 5).
Splenectomy has been recommended as the initial treatment when therapy is
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GOLOMB HM, CATOVSKY D, GOLDE DW. Hairy Cell Leukemia: A Five-Year Update on Seventy-One Patients. Ann Intern Med. 1983;99:485–486. doi: 10.7326/0003-4819-99-4-485
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Published: Ann Intern Med. 1983;99(4):485-486.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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