J. AUWERX, M.D.; D. KNOCKAERT, M.D.; P. HOFKENS, M.D.
AUWERX J, KNOCKAERT D, HOFKENS P. Acyclovir and Neurologic Manifestations. Ann Intern Med. 1983;99:882-883. doi: 10.7326/0003-4819-99-6-882_4
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Published: Ann Intern Med. 1983;99(6):882-883.
To the editor: In their recent article, Wade and Meyers(1) highlighted the neurologic side effects seen during intravenous acyclovir therapy for herpes infections after bone marrow transplantation. We noted a similar reversible neurologic deterioration in an older immunosuppressed patient who was not a marrow recipient.
A 60-year-old woman had a localized herpes zoster infection. Her medical history included a malignant lymphoepithelial thymoma, discovered in the anterior mediastinum in 1969. Because of the extension and local invasion of the tumor, she was treated with radiotherapy (4500 rad), which was followed by an almost complete regression of the tumor and development of
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