EMMANUEL N. DESSYPRIS, M.D.; MARIA R. BAER, M.D.; JOHN S. SERGENT, M.D.; SANFORD B. KRANTZ, M.D.
Three patients with severe, deforming, and long-standing rheumatoid arthritis developed pure red cell aplasia that did not remit after withdrawal of medications, ran a chronic course, and in two patients remitted only after cytotoxic immunosuppressive treatment. An IgG inhibitor of autologous erythroid colony-forming and burst-forming unit growth in vitro was found in the serum of one patient. This specific erythropoietic inhibitor persisted in lower titer in the patient's serum even after an azathioprine-induced remission of pure red cell aplasia, indicating the possible need for maintenance immunosuppressive therapy. Chronic pure red cell aplasia may be another extra-articular manifestation of rheumatoid arthritis and should be considered when severe anemia develops in the absence of blood loss or hemolysis.
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DESSYPRIS EN, BAER MR, SERGENT JS, KRANTZ SB. Rheumatoid Arthritis and Pure Red Cell Aplasia. Ann Intern Med. 1984;100:202–206. doi: 10.7326/0003-4819-100-2-202
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Published: Ann Intern Med. 1984;100(2):202-206.
Hematology/Oncology, Red Cell Disorders, Rheumatoid Arthritis, Rheumatology.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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