The dexamethasone suppression test for the detection, diagnosis, and management of depression consists of two steps. Dexamethasone is administered orally, 1 mg in tablet form, at 2300 h. Then, samples of venous blood are drawn at 0800 h, 1600 h, and 2300 h the following day; in outpatients, only a 1600 h venous blood sample commonly is obtained.
A serum cortisol level greater than 4.5 to 5 µg/dL for any of the blood samples is abnormal and represents a positive test, depending on the assay used (1). Thus, it is important that the laboratory method used be precise and accurate
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The Dexamethasone Suppression Test for the Detection, Diagnosis, and Management of Depression. Ann Intern Med. 1984;100:307-308. doi: 10.7326/0003-4819-100-2-307
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Published: Ann Intern Med. 1984;100(2):307-308.
Healthcare Delivery and Policy, Prevention/Screening.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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