JAY W. MARKS, M.D.; SHU-PING LAN; RICHARD A. BAUM, M.D.; ROBERT L. HABIG, Ph.D.; RUSSELL F. HANSON, M.D.; THEODORE HERSH, M.D.; N.C. HIGHTOWER, M.D.; ALAN F. HOFMANN, M.D.; JOHN M. LACHIN, Sc.D.; ELLIOTT C. LASSER, M.D.; HAGOP MEKHJIAN, M.D.; RONALD OKUN, M.D.; ROBERT A. SCHAEFER, M.D.; LESLIE J. SCHOENFIELD, M.D.; ROGER D. SOLOWAY, M.D.; JOHNSON L. THISTLE, M.D.; FRED B. THOMAS, M.D.; MALCOLM P. TYOR, M.D.
MARKS JW, LAN S, BAUM RA, HABIG RL, HANSON RF, HERSH T, et al. Low-Dose Chenodiol to Prevent Gallstone Recurrence After Dissolution Therapy. Ann Intern Med. 1984;100:376-381. doi: 10.7326/0003-4819-100-3-376
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Published: Ann Intern Med. 1984;100(3):376-381.
Chenodiol is a safe and effective agent for the medical dissolution of gallstones in selected patients; however, after dissolution and cessation of treatment, gallstones recur. This study was done to determine the recurrence rate after successful medical treatment and cessation of chenodiol therapy; compare the efficacy and safety of low-dose chenodiol, as compared to placebo, for prophylaxis against recurrence; and identify factors predictive of recurrence. In a randomized, double-blind fashion, 53 patients with gallstone dissolution received either chenodiol, 375 mg/d, or placebo, for at least 2 years. Standardized oral cholecystograms were done at 6 months, 1 year, and then yearly thereafter. Routine laboratory testing was done every 6 months. The cumulative rate of recurrence (life-table) was 27% in patients followed for up to 3.5 years. Chenodiol, 375 mg/d, was ineffective in preventing the recurrence of gallstones. No demographic, clinical, roentgenographic, or biochemical characteristics were predictive of recurrence.
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Gastroenterology/Hepatology, Biliary Disorders.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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