LESLIE O. SIMPSON, PH.D.
SIMPSON LO. Dietary Protein and Renal Failure. Ann Intern Med. 1984;100:460. doi: 10.7326/0003-4819-100-3-460_1
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Published: Ann Intern Med. 1984;100(3):460.
To the editor: Different concepts of glomerulonephritis, fashionable for differing periods without providing a basis for changing treatment, were discussed recently by Bertan and Remuzzi (1). Because ultra-high-magnification electron microscopy has failed to provide a morphologic basis for the pore theory on which the proposal of "sustained hyperfiltration" is based, it is possible that this will be another temporarily fashionable concept. There are good reasons for Jamison (2) to express "uneasy doubts" concerning dietary protein and progressive renal failure. Despite the grossly nonphysiologic nature of a model involving removal of most of the renal tissues, the idea of haemodynamically mediated
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