MARGARET M. PARKER, M.D.; JAMES H. SHELHAMER, M.D.; STEPHEN L. BACHARACH, Ph.D.; MICHAEL V. GREEN, M.S.; CHARLES NATANSON, M.D.; TERRI M. FREDERICK, B.S.N.; BARBARA A. DAMSKE, R.N.; JOSEPH E. PARRILLO, M.D.
PARKER MM, SHELHAMER JH, BACHARACH SL, GREEN MV, NATANSON C, FREDERICK TM, et al. Profound but Reversible Myocardial Depression in Patients with Septic Shock. Ann Intern Med. 1984;100:483-490. doi: 10.7326/0003-4819-100-4-483
Download citation file:
Published: Ann Intern Med. 1984;100(4):483-490.
To characterize the role of cardiac function in septic shock, serial radionuclide cineangiographic and hemodynamic evaluations were done on 20 patients with documented septic shock. Although all patients had a normal or elevated cardiac index, 10 patients had moderate to severe depression of their ejection fraction with values below 0.40. Thirteen of twenty patients survived their episode. Paradoxically, 10 of 13 survivors, but none of the 7 nonsurvivors, had an initial ejection fraction less than 0.40 (p < 0.005). The mean initial ejection fraction for the survivors was 0.32 ± 0.04, and their mean end systolic and end diastolic ventricular volumes were substantially increased with a normal stroke volume. The survivors' serial scans showed a gradual return to normal ejection fraction and ventricular volume by 10 days after the onset of shock. Nonsurvivors had normal initial ejection fractions and ventricular volumes that did not change during serial studies.
Learn more about subscription options.
Register Now for a free account.
Cardiology, Infectious Disease, Pulmonary/Critical Care, Multi-Organ Failure and Sepsis.
Results provided by:
Copyright © 2016 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use
This PDF is available to Subscribers Only