MARK FELDMAN, M.D.; J.V NIXON, M.D.; TERESE FINITZO-HIEBER, Ph.D.; FRANCES J FREEMAN, Ph.D.
FELDMAN M, NIXON J, FINITZO-HIEBER T, FREEMAN FJ. Abnormal Parasympathetic Vagal Function in Patients with Spasmodic Dysphonia. Ann Intern Med. 1984;100:491-495. doi: 10.7326/0003-4819-100-4-491
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Published: Ann Intern Med. 1984;100(4):491-495.
Gastric vagal function was assessed in 15 patients with spasmodic dysphonia by measuring gastric acid output in response to sham feeding. Patients secreted significantly less acid than controls (p < 0.001). Cardiac vagal function was assessed in 11 patients by measuring heart rate during deep respiration and also during and after Valsalva maneuver. Patients with spasmodic dysphonia had a significantly reduced fluctuation of heart rate during deep respiration (sinus arrhythmia). The expiratory to inspiratory R-R interval averaged 1.08 ± 0.08 (mean ± SD) in patients and 1.22 ± 0.10 in controls (p < 0.005). The ratio of tachycardia during Valsalva maneuver to bradycardia after Valsalva manuever was also lower in patients than in controls (p < 0.005). The auditory brainstem response was abnormal in 11 of 15 patients. Our results show either a central brainstem abnormality or several cranial nerve abnormalities in some patients with spasmodic dysphonia.
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Cardiac Diagnosis and Imaging, Cardiology, Neurology, Pulmonary/Critical Care, Rhythm Disorders and Devices.
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