KENNETH A. FOON, M.D.; RONALD T. MITSUYASU, M.D.; ROBERT W. SCHROFF, Ph.D.; ROSEMARY E. McINTYRE, M.D.; RICHARD CHAMPLIN, M.D.; ROBERT PETER GALE, M.D.
FOON KA, MITSUYASU RT, SCHROFF RW, McINTYRE RE, CHAMPLIN R, GALE RP. Immunologic Defects in Young Male Patients with Hepatitis-Associated Aplastic Anemia. Ann Intern Med. 1984;100:657-662. doi: 10.7326/0003-4819-100-5-657
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Published: Ann Intern Med. 1984;100(5):657-662.
Extensive immunologic studies were done in 97 patients with severe aplastic anemia between 1973 and 1979. Sixteen young male patients with hepatitis-associated aplastic anemia appeared to constitute a unique subset. Compared with most patients with aplastic anemia from other causes, these 16 patients had significant reductions in the mean values of circulating T lymphocytes, serum IgG and IgM, mitogen reactivity, and decreased cutaneous hypersensitivity. The ratio of peripheral blood helper to suppressor T lymphocytes identified by monoclonal antibodies was within normal limits in 3 patients studied with hepatitis-associated aplastic anemia. Interestingly, the ratio was low (< 1) in 3 of 7 patients studied with aplastic anemia from other causes, although the mean for these 7 patients was normal. These data suggest that patients in this subset with hepatitis-associated severe aplastic anemia have a severe immunodeficiency. Whether this immunodeficiency is the cause or result of the hepatitis or aplastic anemia, or both, is unknown.
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Gastroenterology/Hepatology, Hematology/Oncology, Red Cell Disorders, Liver Disease.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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