J. BRUCE L. McCLAIN; W. RIPLEY BALLOU; SHANNON M. HARRISON; DONALD L. STEINWEG
To study antibiotic efficacy, 29 patients with leptospirosis were treated in a randomized, double-blinded fashion with doxycyline, 100 mg orally twice a day, or placebo. Therapy was given for 7 days in a hospital, and patients were followed for 3 weeks afterwards. Duration of illness before therapy and severity of illness were the same in both groups. Doxycycline reduced the duration of illness by 2 days and favorably affected fever, malaise, headache, and myalgias. Treatment prevented leptospiruria and had no adverse effects. Doxycyline is effective in therapy for patients with leptospirosis.
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McCLAIN JBL, BALLOU WR, HARRISON SM, STEINWEG DL. Doxycycline Therapy for Leptospirosis. Ann Intern Med. 1984;100:696-698. doi: 10.7326/0003-4819-100-5-696
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Published: Ann Intern Med. 1984;100(5):696-698.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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