PATRICK J. LOEHRER, M.D.; LAWRENCE H. EINHORN, M.D.
Cisplatin is a metal coordination compound that was approved for clinical use in treating testicular cancer 5 years ago. Although early trials showed marked gastrointestinal and renal toxicities, treatment-related morbidity has been significantly alleviated with modern antiemetic therapy and adequate pretreatment hydration. More recent clinical studies of cisplatin have shown a broad range of activity and provide a better understanding of the drug's pharmacology, mechanism of action, and toxicity. Variations in the dosage and mode of administration as well as development of cisplatin analogues are being currently studied.
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LOEHRER PJ, EINHORN LH. Cisplatin. Ann Intern Med. 1984;100:704-713. doi: 10.7326/0003-4819-100-5-704
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Published: Ann Intern Med. 1984;100(5):704-713.
Emergency Medicine, Hematology/Oncology.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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