PETER MANU, M.D.
To the editor: Amikacin, a semisynthetic derivative of kanamycin A, was approved for unrestricted clinical use in 1976 and is considered the antibiotic of choice for use against infections with gentamicin-resistant, gram-negative bacilli (1, 2). In a recent issue, Betts and colleagues (3) have reported data on the use of amikacin as the primary empiric aminoglycoside in a large university hospital. The authors have concluded that "because it is not possible to identify patients infected with gentamicin-resistant organisms until 48 hours after therapy is initiated, it is rational to use an antibiotic agent that is likely to be effective against
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MANU P. Empiric Use of Aminoglycosides in Hospitals. Ann Intern Med. 1984;100:919–920. doi: 10.7326/0003-4819-100-6-919_2
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Published: Ann Intern Med. 1984;100(6):919-920.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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