WILLIAM F. FINN, M.D.; LAWRENCE J. HAK, PHARM. D.
To the editor: Moore and associates (1) in their study of aminoglycoside nephrotoxicity conclude that a high initial calculated creatinine clearance, an elevated initial aminoglycoside level, 1 hour after administration of the drug, and the presence of liver disease were among the statistically significant factors associated with subsequent impairment of renal function. We believe there is a simple explanation for these findings, which unfortunately makes the interpretation of their work somewhat doubtful.
It should be noted that the nomogram of Chan and colleagues (2) was used to decide on the loading and maintenance doses of aminoglycosides. This nomogram compares the
Learn more about subscription options.
Register Now for a free account.
FINN WF, HAK LJ. Liver Disease, Creatinine Clearance, and Aminoglycoside Nephrotoxicity. Ann Intern Med. 1984;101:277–278. doi: 10.7326/0003-4819-101-2-277_2
Download citation file:
Published: Ann Intern Med. 1984;101(2):277-278.
Copyright © 2017 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use
This PDF is available to Subscribers Only