ELLEN K. MITCHELL, M.D.
To the editor: It has recently come to our attention that flucytosine can produce a falsely elevated serum creatinine.
A 63-year-old white man had been treated with steroids for a blood dyscrasia. He presented in January 1984 with a 1-month history of headache, fever, eye pain, confusion and dysarthria. He was diagnosed as having cryptococcal meningitis and was treated with amphotericin B (0.4 mg/kg body weight •d) and flucytosine (125 mg/kg body weight •d). During his treatment blood samples for serum creatinine were run simultaneously on both the ACA (Dupont Instruments, Wilmington, Delaware) and EKTACHEM (Eastman Kodak Co., Rochester, New
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MITCHELL EK. Flucytosine and False Elevation of Serum Creatinine Level. Ann Intern Med. 1984;101:278. doi: 10.7326/0003-4819-101-2-278_1
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Published: Ann Intern Med. 1984;101(2):278.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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