PETER BALCKE, M.D.; PAUL SCHMIDT, M.D.; JAN ZAZGORNIK, M.D.; HERBERT KOPSA, M.D.; ALEXANDER HAUBENSTOCK, M.D.
BALCKE P, SCHMIDT P, ZAZGORNIK J, KOPSA H, HAUBENSTOCK A. Ascorbic Acid Aggravates Secondary Hyperoxalemia in Patients on Chronic Hemodialysis. Ann Intern Med. 1984;101:344-345. doi: 10.7326/0003-4819-101-3-344
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Published: Ann Intern Med. 1984;101(3):344-345.
A deficiency in ascorbic acid is found in many patients having chronic hemodialysis treatment, and supplementation is commonly recommended. Ascorbic acid is a metabolic precursor of oxalic acid. Because this compound accumulates during chronic renal insufficiency (1), the administration of ascorbic acid could cause a further increase of plasma oxalic acid levels in patients on chronic hemodialysis.
Over a period of 4 weeks, nine patients on chronic hemodialysis (seven men, two women; mean age, 41 years) received 1 g of ascorbic acid intravenously after each dialysis session, or a total dose of 12 g for each patient. The clinical diagnosis
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Nephrology, Renal Replacement Therapy.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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