RICHARD F. BAKEMEIER, M.D.; JAMES R. ANDERSON, Ph.D.; WILLIAM COSTELLO, Ph.D.; GARY ROSNER, M.S.; JOHN HORTON, M.B., Ch.B.; JOHN H. GLICK, M.D.; JOHN D. HINES, M.D.; COSTAN W. BERARD, M.D.; VINCENT T. DeVITA, M.D.
BAKEMEIER RF, ANDERSON JR, COSTELLO W, ROSNER G, HORTON J, GLICK JH, et al. BCVPP Chemotherapy for Advanced Hodgkin's Disease: Evidence for Greater Duration of Complete Remission, Greater Survival, and Less Toxicity Than with a MOPP Regimen: Results of the Eastern Cooperative Oncology Group Study. Ann Intern Med. 1984;101:447-456. doi: 10.7326/0003-4819-101-4-447
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Published: Ann Intern Med. 1984;101(4):447-456.
Two chemotherapy regimens for treatment of patients with advanced Hodgkin's disease, BCVPP (carmustine, cyclophosphamide, vinblastine, procarbazine, and prednisone) and MOPP (mechlorethamine hydrochloride, vincristine, procarbazine, and prednisone), were compared in a randomized prospective study. Two hundred ninety-three patients were evaluable in the induction phase of this study. The complete remission rate with BCVPP was 76% (112/147) and with MOPP, 73% (106/146) (p = 0.51). The duration of complete remissions for previously untreated patients given BCVPP was significantly longer than that for previously untreated patients given MOPP (p = 0.02). Although hematologic toxicities were similar, BCVPP caused less gastrointestinal (p = 0.0001) and neurologic toxicity (p = 0.01) than MOPP. Previously untreated patients achieving complete remission with BCVPP survived significantly longer than those receiving MOPP (p = 0.03). As primary induction chemotherapy for advanced Hodgkin's disease, BCVPP is an effective alternative to MOPP, having equal or greater therapeutic benefit with less toxicity.
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Emergency Medicine, Hematology/Oncology, Leukemia/Lymphoma.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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