PAUL A. BUNN, M.D.; KENNETH A. FOON, M.D.; DANIEL C. IHDE, M.D.; DAN L. LONGO, M.D.; JOYCE EDDY, R.N.; CHARLES F. WINKLER, M.D.; STEPHEN R. VEACH, M.D.; JACOB ZEFFREN, M.D.; STEVEN SHERWIN, M.D.; ROBERT OLDHAM, M.D.
BUNN PA, FOON KA, IHDE DC, LONGO DL, EDDY J, WINKLER CF, et al. Recombinant Leukocyte A Interferon: An Active Agent in Advanced Cutaneous T-Cell Lymphomas. Ann Intern Med. 1984;101:484-487. doi: 10.7326/0003-4819-101-4-484
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Published: Ann Intern Med. 1984;101(4):484-487.
High-dose recombinant leukocyte A interferon (50 X 106 U/m2 body surface area, intramuscularly, three times weekly) was tested in a clinical trial involving patients with advanced cutaneous T-cell lymphomas to determine its effectiveness and toxicity. All 20 patients had advanced stages of disease refractory to two or more standard therapies. Objective partial remissions lasting 3 months to more than 25 months (median, 5 months) were documented in 9 patients. The major dose-limiting toxicity was a severe influenza-like syndrome with malaise, anorexia, depression, weight loss, and decreased performance status; this effect was reversible after dose reductions in all patients and did not recur with re-escalation of doses in 10 patients. This interferon preparation is highly effective in the treatment of advanced refractory cutaneous T-cell lymphomas, and new schedules to reduce toxicity and achieve complete responses, combined treatment with chemotherapy or serotherapy, and its use in earlier stages of disease should be investigated.
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