LOREN WISSNER GREENE, M. D.; WILLIAM COLE, M.D.; JEFFREY B. GREENE, M.D.; BRIAN LEVY, M.D.; EDDIE LOUIE, M.D.; BRUCE RAPHAEL, M.D.; H. JOAN WAITKEVICZ, M.D.; MANFRED BLUM, M.D.
GREENE LW, COLE W, GREENE JB, LEVY B, LOUIE E, RAPHAEL B, et al. Adrenal Insufficiency as a Complication of the Acquired Immunodeficiency Syndrome. Ann Intern Med. 1984;101:497-498. doi: 10.7326/0003-4819-101-4-497
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Published: Ann Intern Med. 1984;101(4):497-498.
Since the acquired immunodeficiency syndrome was recognized in 1980, various malignancies, infections, and immunologic defects have been found in the affected population. Recently, adrenal necrosis was found at autopsy in ten patients who died of the syndrome (1). Seven of these patients had cytomegalovirus infiltration of the adrenal glands. Whether these patients had adrenal insufficiency is unknown, but this disorder was not suspected before their deaths and no chemical studies were done. A subsequent report described adrenal insufficiency preceding immunodeficiency in one patient (2). However, it remains to be ascertained whether Addison's disease is a feature of the syndrome.
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